|
KMID : 0359319970370030533
|
|
Korean Journal of Veterinary Research
1997 Volume.37 No. 3 p.533 ~ p.540
|
|
|
Effects of purinergic nerve on relaxation of pig coronary artery
|
|
Kim Joo-Heon
Shim Cheol-Soo
Jeon Seok-Cheol
|
|
|
Abstract
|
|
|
|
To elucidate the effects of purinergic nerve on relaxation of pig coronary artery, the effects of ATP, 2-methylthio ATP and electrical perivascular nerve stimulation were investigated from physiograph on the isolated coronary artery of pig. The results btained were as follows; 1. The relaxative responses induced by perivascular nerve stimulation(20V, 0.5msec, 10sec) were the frequency(1~8Hz) dependent manner with phentolamine(10^-5M) and atropine(10^-6M) on isolated coronary artery of pig. 2. The relaxative responses induced. by adenosine(10^-7~5x10^-3M) or ATP(10^{-7}~5x10^{-5}M) on precontraction with histamine(10^{-5}M) were the dose-dependent manner, but the contractile responses were often induced by ATP(10^{-4}M and 10^{-3}M). 3. The relaxative responses induced by 2-methylthio ATP(2.5x10^{-8}~2.5x10^{-6}M) on precontraction with histamine(10^{-5}M) were the dose-dependent manner. 4. The relaxative response induced by 2-methylthio ATP(10^{-7}M) on precontraction with histamine(10^{-5}M) was completely blocked by the pretreatment with P2Y-purinoceptor blocker, reactive blue 2(10^{-4}M). 5. The neurogenic relaxative response induced by perivascular nerve stimulation(20V, 8Hz, 0.5msec, 10sec) was weakly inhibited by the pretreatment with β-adrenoceptor blocker, propranolol(10^{-5}M) and blocked by the addition with P2Y-purinoceptor blocker, reactive blue 2(10^{-4}M). The results suggest that the purinergic nerve is innervated, and its relaxative response was mediated by P2Y-purinoceptor on isolated coronary artery in pig.
|
|
|
KEYWORD
|
|
|
2-methylthio ATP , P2Y-purinoceptor , perivascular nerve stimulation , neurogenic relaxation , coronary artery , pig
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|